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Lisinopril and Hydrochlorothiazide 20mg/12.5mg Tablet is not to be used as initial ... If this is not possible, treatment should be started with lisinopril alone, in a 2.5 mg dose. ... or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1). ...... The Urban Building, 2nd Floor, 3-9 Albert Street, Slough, SL1 2BE.

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. As with all other medication taken once daily, lisinopril and hydrochlorothiazide 20mg12. If possible, the diuretic should be discontinued 2 to 3 days before beginning therapy with lisinopril.

Dosage in patients with renal impairment should be based on creatinine clearance as outlined in table 1 below. The dose should be individualised according to patient profile and blood pressure response (see section 4. A lower starting dose is required in the presence of renal impairment (see table 1 below).

The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily. The maximum dose used in long-term, controlled clinical trials was 80 mgday. Thiazides may not be appropriate diuretics for use in patients with renal impairment and are ineffective at creatinine clearance values of 30mlmin or below (i.

Tablet is not to be used as initial therapy in any patient with renal insufficiency. When suggestions are available use up and down arrows to review and enter to select. Short-term (6 weeks) treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction.

The subsequent dosage of lisinopril should be adjusted according to blood pressure response. In patients with hypertension the usual recommended starting dose is 10 mg. In clinical studies, age did not affect the tolerability of lisinopril.

The scoreline is only to facilitate breaking for ease of swallowing and not to divide into equal doses. The dosage should be individually adjusted to a maximum of 20 mg daily in patients weighing 20 to. Lisinopril may be used as monotherapy or in combination with other classes of antihypertensive therapy (see sections 4. In general, if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks at this dose level, the dose can be increased to two tablets administered once daily. In patients with creatinine clearance of 30 and).


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Each uncoated tablet contains lisinopril dihydrate equivalent to 2.5 mg of .... mellitus or renal impairment (GFR < 60 ml/min/1.73 m2) (see sections 4.5 and 5.1 ).

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    Dosage in patients with renal impairment should be based on creatinine clearance as outlined in table 1 below. The subsequent dosage of lisinopril should be adjusted according to blood pressure response. Lisinopril may be used as monotherapy or in combination with other classes of antihypertensive therapy (see sections 4. In general if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks on a certain dose level, the dose can be further increased. In hypertensive patients in whom the diuretic cannot be discontinued, therapy with lisinopril should be initiated with a 5 mg dose.

    Short-term (6 weeks) treatment of haemodynamically stable patients within 24 hours of an acute myocardial infarction. The maximum dose used in long-term, controlled clinical trials was 80 mgday. In general, if the desired therapeutic effect cannot be achieved in a period of 2 to 4 weeks at this dose level, the dose can be increased to two tablets administered once daily. The dose should be individualised according to patient profile and blood pressure response (see section 4. When suggestions are available use up and down arrows to review and enter to select.

    The scoreline is only to facilitate breaking for ease of swallowing and not to divide into equal doses. Caution is recommended therefore, since these patients may be volume andor salt depleted. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily. The dosage should be individually adjusted to a maximum of 20 mg daily in patients weighing 20 to. If possible, the diuretic should be discontinued 2 to 3 days before beginning therapy with lisinopril. Tablets should be taken at approximately the same time each day. As with all other medication taken once daily, lisinopril and hydrochlorothiazide 20mg12. Tablet is not to be used as initial therapy in any patient with renal insufficiency. . Thiazides may not be appropriate diuretics for use in patients with renal impairment and are ineffective at creatinine clearance values of 30mlmin or below (i.

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